Is there a possability to make Plugins only work in a certain zone? 

Whichever plugin offers the functionality that you want to be zonal would likely have to support it.

If the plugins you are thinking of have sufficient hooks, then you could write a simple add on plugin to block their functionality in certain zones (based on zone ids in a config). This is ideal from a modularity standpoint as it's not contingent on the either the functionality-providing plugin or Zone Manager to be updated to do it.

it's about this plugin: https://umod.org/community/night-zombies/34144-zombies-in-a-zone
But i would be happy if there would be a solution for all plugins.