I have a player reporting to me that when him and a friend tried the new handcuffs, the player handcuffed lost everything in his backpack (this mod one, not the Rust one). It will be later tonight before I can test this, but figured I'd put this here, in case others are running into the same thing.

I really doubt this would be possible because the backpack is simply an external container and the player's state can't effect it. It would be like saying that the player getting handcuffs put on them made loot disappear from their base.